2021年:ラボメンバーの実績の紹介

投稿日 から Kohei Hasegawa · コメントする

ラボの実績はすなわちメンバーの成長です。
メンバーの成長を客観的に提示するのは難しいですが、2021年の実績を通じてラボメンバーたちの自慢をさせてください。

  • Dr. Raita: 2020年に引き続き、マルチオミクス手法を利用し教科書を書きかえるようなlandmark的な論文を次々と出版。最新のものはEur Respir Jから出版されたメタトランスクリプトーム論文です。ラボを卒業して寂しくなりましたが、日本での活躍を応援しています！

  • Dr. Fujiogi: 今年は後輩指導の主役かつmetabolome解析のエクスパートであることに加え、マルチオミクスの大きな論文も書き上げました（査読中）。あと数ヶ月で卒業ですが、現在は世界最大の気道リピドーム研究に取り組んでいます。

  • Dr. Nanishi: ラボに参加し1年です。すでに3本の論文を筆頭出版（どれも一流の学会official journalから）。Clinical expertとしての知識および精神的支柱としてラボにも大きく貢献。これからも期待してます。

  • Dr. Ooka: 12月から参加となった大型新人！1年前より留学準備と僕らとコラボをはじめており、すでに一本のプロテオーム論文を出版。大型グラントも次々と獲得。アカデミア・そしてそれを超えていく成長がたのしみです。

  • Dr. Zhu: かつてはGWASのエキスパートでしたが、他のオミクスデータを扱えるようにさらなる成長を遂げています。ことしはNIH以外のグラントをとること・研究指導の役割の増大を期待しています。

  • 自分：MGH救急部・NIHの仕事（雑用？）に忙殺されたなか、ラボメンバーから支えてもらい多くを教えてもらいました。感謝しています。

ラボメンバーのみんな・外部コラボレーターの力を結集して、合計40本の原著論文（査読中は含まず）および7本のレビュー論文などを出版しました。とくに我々の業界のleading journalsである Lancet Respir Med, Am J Respir Crit Care Med, Allergy, J Allergy Clin Immunolなどから出版しています。来年はさらに質を深める方向でいきます（数は減らしてもいい）。以下がリストとなります。

  1. Raita Y, Perez-Losada, Freishtat RJ, Hahn A, Castro-Nallar E, Ramos-Tapia I, Stearrett N, Bochkov YA, Gern JA, Mansbach JM, Zhu Z, Camargo CA Jr., Hasegawa K. Nasopharyngeal metatranscriptome profiles of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study. Eur Respir J 2021; in press
  2. Zhu Z, Camargo CA Jr., Raita Y, Fujiogi M, Liang L, Rhee EP, Woodruff P, Hasegawa K. Metabolome subtyping of severe bronchiolitis in infant and risk of childhood asthma. J Allergy Clin Immunol 2021; online ahead of print
  3. Fujiogi, M, Camargo CA Jr, Raita Y, Toivonen L, Freishtat RJ, Mansbach JM, Piedra PA, Hasegawa K. Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: A prospective multicenter study. Pediatr Res 2021;89:1594-1597
  4. Patregnani JT (co-first), Fujiogi M (co-first), Camargo CA Jr., Brooks BA, Hoptay CE, Mansbach JM, Teach SJ, Freishtat RJ, Hasegawa K. Serum soluble receptor for advanced glycation end-products (sRAGE) in infants with bronchiolitis: Associations with acute severity and recurrent wheeze. Clin Infect Dis 2021; online ahead of print
  5. Geller RJ, Espinola JA, Hasegawa K,Mansbach JM, Sullivan AF, Camargo CA Jr. A comparison of childhood asthma case definitions based on parent-reported data. Ann Epidemiol 2021;55:64-68.e4
  6. Funakoshi H, Kunitani Y, Goto T, Okamoto H, Hagiwara Y, Watase H, Hasegawa K. Association between repeated tracheal intubation attempts and adverse events in children in the emergency department. Pediatr Emerg Care 2021; online ahead of print.
  7. Raita Y, Camargo CA Jr., Bochkov YA, Celedon JC, Gern JE, Mansbach JM, Rhee EP, Freishtat RJ, Hasegawa K. Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma. J Allergy Clin Immunol 2021;147:2108-2117
  8. Chen Arroyo AJ, Robinson LB, Geller RJ, Rudders S, Sullivan AF, Hasegawa K, Camargo CA Jr. Allergic sensitization during early life: Concordance between ImmunoCAP and ISAC results. J Allergy Clin Immunol Pract 2021;9(5):2126-2128.e3
  9. Kochav SM, Raita Y, Fifer MA, Takayama H, Ginns J, Maurer MS, Reilly MP, Hasegawa K, YJ Shimada. Predicting the development of adverse cardiac events in patients with hypertrophic cardiomyopathy using machine learning. Intern J Cardiol 2021;327:117-124
  10. Mansbach JM, Geller RJ, Hasegawa K, Piedra PA, Avadhanula V, Gern JE, Bochkov YA, Espinola JA, Sullivan AF, Camargo CA Jr. Detection of respiratory syncytial virus or rhinovirus weeks after hospitalization for bronchiolitis and the risk of recurrent wheezing. J Infect Dis 2021;223(2):268-277
  11. Sahashi Y, Endo H, Sugimoto T, Nabeta T, Nishizaki K, Kikuchi A, Matsumoto S, Sato H, Goto T, Hasegawa K, Matsue Y. Worries and concerns among healthcare workers during the coronavirus 2019 pandemic: A web-based cross-sectional survey. Human Social Sci Comm 2021;8:41
  12. Samuels-Kalow ME, Boggs KM, Cash RE, Herrington R, Mick NW, Rutman MS, Venkatesh AK, Zabbo CP, Sullivan AF, Hasegawa K, Zacharison, KS, Camargo CA Jr. Screening for Health-related social needs of emergency department patients. Ann Emerg Med 2021;77(1):62-68.
  13. Shimada YJ, Batra J, Kochav SM, Patel P, Jung J, Maurer MS, Hasegawa K, Reilly MP, Fifer MA. Difference in metabolomic response to exercise between patients with and without hypertrophic cardiomyopathy. J Cardiovasc Transl Res 2021;14(2):246-255
  14. Choi T, Devries M, Bacharier L, Busse W, Camargo CA Jr., Cohen R, Demuri GP, Evans MD, Fitzpatrick AM, Gergen PJ, Grindle K, Gruchalla R, Hartert T, Hasegawa K, Hershey GKK, Holt P, Homil K, Jartti T, Kattan M, Kercsmar C, Haejin K, Laing IA, LeBeau P, Lee kE, Le Souef, PN, Liu A, Mauger DT, Ober C, Pappas T, Patel SJ, Phipatanakul W, Pongracic J, Seroogy C, Sly PD, Tiesler C, Wald ER, Wood R, Gangron R, Jackson DJ, Lemanske RF Jr., Gern JE, Bochkov YA. Enhanced neutralizing antibody responses to rhinovirus C and age-dependent patterns of infection. Am J Respir Crit Care Med 2021;203(7):822-830.
  15. Boggs KM, Espinola JA, Sullivan AF, Freid RD, Auerbach M, Hasegawa K, Samuels-Kalow ME, Camargo CA Jr. Availability of pediatric emergency care coordinators in U.S. emergency departments. J Pediatr 2021;235:163-169.e1
  16. Raita Y, Zhu Z, Freishtat RJ, Fujiogi M, Liang L, Patregnani JT, Camargo CA Jr., Hasegawa K. Soluble receptor for advanced glycation end products (sRAGE) and asthma: Mendelian randomisation study. Pediatr Allergy Immunol 2021;32(5):1100-1103
  17. Takahashi J, Goto T, Funakoshi H, Okamoto H, Hagiwara Y, Watase H, Hasegawa K. Association of advanced age with intubation-related adverse events in the emergency department: A multicenter prospective observational study. Emerg Med J 2021; online ahead of print
  18. Fujiogi M, Camargo CA Jr., Raita Y, Zhu Z, Celedon JC, Mansbach JM, Spergel JM, Hasegawa K. Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study. Pediatr Allergy Immunol2021;32(5):905-916
  19. Zhu Z, Li J, Si J, Ma B, Shi H, L, Cao W, Guo Y, Millwood I, Walters R, Lin K, Yang L, Chen Y, Du H, Yu B, Hasegawa K, Camargo CA Jr, Moffatt M, Cookson W, Chen J, Chen Z; Li L, Yu C, Liang L. A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity. Eur Respir J 2021;58:2100199
  20. Liang LW, Fifer MA, Hasegawa K, Maurer MS, Reilly MP, Shimada YJ. Prediction of genotype positivity in patients with hypertrophic cardiomyopathy using machine learning. Circ Genom Precis Med 2021; online ahead of print
  21. Raita Y, Zhu Z, Camargo CA Jr., Freishtat RJ, Ngo D, Liang L, Hasegawa K. Relationship of soluble interleukin-6 receptors with asthma: A Mendelian randomization study. *Frontier Med *2021;8:442
  22. Arroyo AJ, Robinson LB, Cash RE, Faridi MK, Hasegawa K, Camargo CA Jr. Trends in emergency department visits and hospitalizations for anaphylaxis among US older adults: 2006-2014. J Allergy Clin Immunol Pract; 2021; online ahead of print
  23. Raita Y, Pérez-Losada M, Freishtat RJ, Harmon B, Mansbach JM, Piedra PA, Zhu Z, Camargo CA Jr., Hasegawa K. Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma. Nat Commun2021;12(1):3601.
  24. Shimada YJ, Raita Y, Liang LW, Mauer MS, Hasegawa K, Fifer MA, Reilly MP. Comprehensive proteomics profiling reveals molecular pathway that is differentially regulated in hypertrophic cardiomyopathy and correlated with clinical markers of disease severity. Circ Heart Failure 2021; in press
  25. Mitri EJ, Zheng DX, Garg V, Crifase CC, Herrera NM, Espinola JA, Hasegawa K, Camargo CA Jr. Blood eosinophils, specific immunoglobulin E, and bronchiolitis severity. Pediatr Pulm 2021; online ahead of print
  26. Nanishi M, Press VG, Miller JB, Eastin C, Aurora T, Crocker E, Fujiogi M, Camargo CA Jr., Hasegawa K. Hospital-initiated care bundle, post-hospitalization care, and outcomes in adults with asthma exacerbation. J Allergy Clin Immunol Pract 2021;S2213-2198(21)00775-3
  27. Morita SX, Kusunose K, Haga A, Sata M, Hasegawa K, Raita Y, Reilly MP, Fifer MA, Maurer MS, Shimada YJ. Deep learning analysis of echocardiographic images to predict positive genotype in patients with hypertrophic cardiomyopathy. Front Cardiovasc Med 2021;8:669860
  28. Myers L, Faridi M, Hasegawa K, Camargo CA Jr. Pulmonary rehabilitation and readmission rates for Medicare beneficiaries with acute exacerbations of chronic obstructive pulmonary disease. Chronic Obstr Pulm Dis 2021; online ahead of print
  29. Vitko D, McQuaid JW, Gheinani AH, Hasegawa K, DiMartino S, Davis KH, Chung CY, Petrosino JF, Adam RM, Mansbach JM, Lee R. Urinary tract infections in children with vesicoureteral reflux are accompanied by alterations in urinary microbiota and metabolome profiles. Eur Urolol 2021;S0302-2838(21)01990-4
  30. Dumas O, Erkkola R, Bergroth E, Hasegawa K, Mansbach JM, Piedra PA, Jartti T, Camargo CA Jr. Severe bronchiolitis profiles and risk of asthma development in Finnish children. J Allergy Clin Immunol 2021; in press
  31. Morita SX, Zhao Y, Hasegawa K, Fifer MA, Maurer MS, Reilly MP, Takayama H, Shimada YJ. Effects of septal reduction therapy on acute cardiovascular events and all-cause mortality in patients with hypertrophic cardiomyopathy. Int Heart J 2021;62:1035-1041
  32. Mansbach JM, Qi Y, Espinola JA, Hasegawa K, Puls HT, Sullivan AF, Camargo CA Jr. Late pre-term infants with severe bronchiolitis and risk of asthma by age 5 years. J Pediatr 2021; online ahead of print
  33. Filho RCF, Geller RJ, Santos LC, Espinola JA, Robinson LB, Hasegawa K, Camargo CA Jr. Performance of three asthma predictive tools in a cohort of infants hospitalized with severe bronchiolitis. Front Allergy 2021;in press
  34. Ooka T, Raita Y, Ngo D, Mansbach JM, Zhu Z, Camargo CA Jr., Hasegawa K. Proteome signature difference between respiratory viruses is associated with severity of bronchiolitis. Pediatr Allergy Immunol 2021; online ahead of print
  35. Boggs KM, Espinola JA, Sullivan AF, Li J, Auerbach M, Hasegawa K, Samuels-Kalow ME, Camargo CA Jr. Availability of Pediatric Emergency Care Coordinators in US emergency departments in 2018. Pediatr Emerg Care 2021; in press.
  36. Nanishi M, Fujiogi M, Stevenson M, Liang L, Qi YS, Raita Y, Hasegawa K, Camargo CA Jr. Association of growth trajectory profiles with asthma development in infants hospitalized with bronchiolitis. J Allergy Clin Immunol Pract 2021; in press
  37. Broderick DTJ, Waite DW, Marsh RL, Camargo CA, Jr., Cardenas P, Chang AB, Cookson WOC, Cuthberston L, Dai W, Everard ML, Gervaix A, Harris K, Hasegawa K, Hoffman LR, Hong S, Josset L, Kelly MS, Kim B, Kong Y, Li SC, Mansbach JM, Mejias A, O’Toole GA, Paalanen L, Perez-Losada M, Pettigrew MM, Pichon M, Ramilo O, Ruokolainen L, Sakwinska O, Seed PC, van der Gast CJ, Wagner BD, Yi H, Zermaanick ET, Zhen Y, Pillarisetti N, Taylor MW. Bacterial signatures of paediatric respiratory disease: a 16S rRNA meta-analysis based on individual participant data. Frontier Microbiol 2021; in press
  38. Yamanaka S, Goto T, Morikawa K, Watase H, Okamoto H, Hagiwara Y, Hasegawa K. Machine learning approaches for difficult airway and first-pass success in the emergency department: Multicenter prospective observational study. Inter J Medical Res 2021; in press
  39. Fujiogi M, Dumas O, Hasegawa K, Jartti T, Camargo CA Jr. Identifying and predicting severe bronchiolitis profiles at high risk for developing asthma: Analysis of three prospective cohorts. EClinicalMedicine 2021; in press
  40. Nanishi M, Fujiogi M, Freishtat RJ, Hoptay CE, Bauer CS, Stevenson MD, Camargo CA Jr., Hasegawa K. Serum periostin among infants with severe bronchiolitis and risk of developing asthma: A prospective multicenter cohort study. Allergy 2021; in press
  41. Zhu Z, Hasegawa K, Camargo CA Jr., Liang L. Investigating asthma heterogeneity through shared and distinct genetics: insights from genome-wide cross-trait analysis. J Allergy Clin Immunol 2021;147(3):796-807
  42. Hasegawa K, Craig SS, Teach SJ, Camargo CA Jr. Management of asthma exacerbations in the emergency department. J Allergy Clin Immunol Pract 2021; online ahead of print
  43. Makrinioti H, Cutovic A, Hasegawa K, Camargo CA Jr., Jartti T. The role of interferons in preschool wheeze. Lancet Respir Med 2021;9:9-11.
  44. Raita Y, Camargo CA Jr., Liang L, Hasegawa K. Invited review: Leveraging “big data” in respiratory medicine — Data science, causal inference, and precision medicine. Exp Rev Respir Med 2021 Apr 15;1-5
  45. Raita Y, Camargo CA Jr., Liang L, Hasegawa K. Big data, data science, and causal inference: A primer for clinicians. Frontier Med 2021;8:678047
  46. Hasegawa K, Mansbach JM. Role of nasal microbiota and host response in infants with respiratory syncytial virus infection: Causal questions about respiratory outcomes. J Allergy Clin Immunol2021; in press
  47. Makrinioti H, Bush A, Gern JE, Johnston S, Papadopoulos NG, Feleszko W, Camargo CA Jr.Hasegawa K, Jartti T. The role of interferons in driving susceptibility to asthma following bronchiolitis: Controversies and research gaps. Frontiers Immunol 2021;3;12:761660

コメントを残す

メールアドレスが公開されることはありません。 * が付いている欄は必須項目です