2019年は当ラボにとって新たな飛躍の年になりました。
強みの違う新メンバーが二人加わり、皆で学び合うレベルの高い環境ができてきました。
4人の多国籍フェロー（日本、中国、フィンランド）が、自ら学びの多い雰囲気のいいラボにしてくれています。

成果の一つの指標である原著論文数は34本 (加えて2本の総説論文)でした。
内容もinnovativeなものが多く、各領域のleading journals (e.g., J Allergy Clin Immunol, JAMA Pediatr, Eur Respir J, Pediatrics, Resuscitation, Ann Emerg Med)から出版されました。

2020年もフェローのさらなる活躍が楽しみです！

Original research articles in 2019
1. Raita Y, Goto T, Faridi MK, Brown DFM, Camargo CA Jr, Hasegawa K. Emergency department triage prediction of clinical outcomes using machine learning models. Crit Care 2019;23:64.
2. Fujiogi M, Goto T, Yasunaga H, Fujishiro J, Mansbach JM, Camargo CA Jr., Hasegawa K. Trends in bronchiolitis hospitalizations in the United States, 2000-2016. Pediatrics 2019; in press
3. Raita Y, Camargo CA Jr., Faridi MK, Brown DFM, Shimada YJ, Hasegawa K. Risk of acute myocardial infarction and ischemic stroke in patients with asthma exacerbation: A population-based, self-controlled case series study. J Allergy Clin Immunol Pract 2019; Epub ahead of print
4. Hasegawa K, Mansbach JM, Bochkov YA, Gern JE, Piedra PA, Bauer CS, Teach SJ, Wu S, Sullivan AF, Camargo CA Jr. Association of rhinovirus-C bronchiolitis and IgE sensitization during infancy with development of recurrent wheeze: A multicenter prospective cohort study. JAMA Pediatr 2019;173:544-552
5. Toivonen L, Camargo Ca Jr, Gern JE, Bochkov YA, Mansbach JM, Piedra PA, Hasegawa K. Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis. J Allergy Clin Immunol 2019;143:1925-1928
6. Okamoto H, Goto T, Wong ZSY, Hagiwara Y, Watase H, Hasegawa K. Comparison of video laryngoscopy versus direct laryngoscopy for intubation in emergency department patients with cardiac arrest: A multicentre study. Resuscitation2019:136:70-77
7. Dumas O, Hasegawa K, Mansbach JM, Sullivan AF, Piedra PA, Camargo CA Jr. Severe bronchiolitis profiles and risk of developing recurrent wheezing by age 3 years. J Allergy Clin Immunol 2019;143:1371-1379
8. Goto T, Camargo CA Jr, Faridi MH, Freishtat RJ, Hasegawa K. Machine learning-based prediction of clinical outcomes for children during emergency department triage. JAMA Netw Open 2019;2:e186937
9. Mansbach JM, Hasegawa K, Piedra PA, Avadhanula V, Petrosino JF, Sullivan AF, Espinola JA, Camargo CA Jr.Haemophilus-dominant nasopharyngeal microbiota is associated with delayed clearance of respiratory syncytial virus in infants hospitalized for bronchiolitis. J Infect Dis. 2019;219:1804-1808
10. Hasegawa K, Goto T, Hirayama A, Laham FR, Mansbach JM, Piedra PA, Camargo CA Jr. Respiratory virus epidemiology among U.S. infants with severe bronchiolitis: Analysis of two multi-center, multi-year cohort studies. Pediatr Infect Dis J 2019;38:e180-e183
11. Dubosh NM, Edlow JA, Goto T, Camargo CA Jr, Hasegawa K. Missed serious neurological conditions in emergency department patients discharged with nonspecific diagnoses of headache or back pain. Ann Emerg Med2019; Epub ahead of print
12. Morikawa M, Hagiwara Y, Gibo K, Goto T, Watase H, Hasegawa K. Methylxanthine use for acute asthma in the emergency department: A multicenter observational study.Acute Med Surg2019;6:279-286
13. Stewart CJ, Mansbach J, Ajami N, Petrosino J, Zhu Z, Liang L, Camargo CA Jr, Hasegawa K. Serum metabolome is associated with nasopharyngeal microbiota and disease severity among infants with bronchiolitis. J Infect Dis2019;219:2005-2014
14. Hasegawa K, Hoptay CE, Harmon B, Celedón JC, Mansbach JM, Piedra PA, Freishtat RJ, Camargo CA Jr. Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy and risk of developing asthma: A multicenter prospective study. Allergy2019; Epub ahead of print
15. Shimada Y, Goto T, Tsugawa Y, Yu EW, Yoshida K, Homma S, Brown DFM, Hasegawa K. Comparative effectiveness of gastric bypass versus gastric banding on acute care use for cardiovascular disease in adults with obesity. Nutr Metab Cardiovasc Dis2019;29:518-526
16. Inoue A, Okamoto H, Hifumi T, Goto T, Hagiwara Y, Watase H, Hasegawa K.The incidence of post-intubation hypertension and association with repeated intubation attempts in the emergency department: Secondary analysis of multicenter prospective observational study. PLoS One 2019;14:e0212170
17. Zhu Z, Wang X, Li Xihao, Lin Y, Liu CL, Hasegawa K, Liang L, Camargo CA Jr, Cho MH, Christiani DC. Genetic overlap between COPD and cardiovascular diseases: A large scale genome-wide cross-trait analysis. Respir Res 2019;20:64
18. Toivonen L, Hasegawa K, Waris M, Ajami NJ, Petrosino JF, Camargo CA Jr, Peltola V. Early nasal microbiota and acute respiratory infections during the first year of life. Thorax 2019;74:592-599
19. Clark S, Boggs KM, Balekian DS, Hasegawa K, Vo P, Rowe CA Jr, MARC-38 Investigators. Changes in emergency department concordance with guidelines for the management of food induced anaphylaxis: 1999-2001 versus 2013-2015. J Allergy Clin Immunol Pract2019; Epub ahead of print
20. Mansbach JM, Geller RJ, Hasegawa K, Espinola JA, Stevenson MD, Sullivan AF, Camargo CA Jr. Association of serum albumin with apnea in infants with bronchiolitis. JAMA Netw Open 2019; in press.
21. Shimada YJ, Hasegawa K, Koch SM, Mohajer P, Jung J, Mauer MS, Reilly MP, Fifer MA. Application of proteomics profiling for biomarker discovery in hypertrophic cardiomyopathy. Cardiovasc Transl Res 2019. Epub ahead of print
22. Stewart CJ, Mansbach JM, Piedra PA, Toivonen L, Camargo CA Jr, Hasegawa K. Association of respiratory viruses with serum metabolome in infants with severe bronchiolitis. Pediatric Allergy Immunol2019; Epub ahead of print
23. Shimada YJ, Goto T, Takayama H, Brown DFM, Homma S, Reilly MP, Maurer MS, Hasegawa K. Comparison of effectiveness of alcohol septal ablation versus ventricular septal myectomy on acute care use for cardiovascular disease in patients with hypertrophic cardiomyopathy. Am J Cardiol2019; in press
24. Mansbach JM, HasegawaK, Geller RJ, Espinola JA, Sullivan AF, Camargo CA Jr. Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort. Pediatr Res2019; in press.
25. Zhu Z, Guo Y, Shi H, Liu CL, Pangniban RA, Chung W, O’Connor LJ, Himes BE, Gazal S, Hasegawa K, Camargo CA Jr., Qi L, Moffatt MF, Hu FB, Lu Q, Cookson WOC, Liang L. Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. J Allergy Clin Immunol2019; in press
26. Tang Y, Dai T Su Z, Hasegawa K, Tian J, Chen L, Wen D. A tripartite microbial-environment network indicates how crucial microbes influence the microbial community ecology. Microb Ecol2019; in press
27. Ishimaru T, Goto T, Takahashi J, Okamoto H, Hagiwara Y, Watase H, Hasegawa K. Association of ketamine use with lower risk of post-intubation hypotension in hemodynamically-unstable patients in the emergency department. Sci Rep2019; in press.
28. Goto Y,Goto T, Okamoto H, Hagiwara Y, Watase H, Hasegawa K. Factors associated with successful rescue intubation attempts in the emergency department: An analysis of multicenter prospective observational study in Japan. Acute Med Surg2019; in press
29. Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K,Camargo CA Jr., Liang L. Shared genetics of asthma and mental health disorders: A large-scale genome-wide cross-trait analysis. Eur Respir J2019; in press
30. Oka S, Goto T, Hirayama A, Faridi MK, Camargo CA Jr., Hasegawa K. Association of obstructive sleep apnea with severity of patents hospitalized for acute asthma. Ann Allergy Asthma Immunol; in press
31. Mansbach JM, Luna PN, Shaw CA, Hasegawa K, Petrosino JF, Piedra PA, Sullivan AF, Espinola JA, Stewart CJ, Camargo CA Jr. Increased Moraxella and Streptococcus abundance following severe bronchiolitis is associated with recurrent wheezing. J Allergy Clin Immunol. 2019; in press
32. Simione M, Harshman SG, Castro I, Linnemann R, Roche B, Ajami JF, Camargo CA Jr., Taveras EM, Hasegawa K (co-senior), Lauran Fiechtner (co-senior). Maternal fish consumption in pregnancy is associated with a Bifidobacterium-dominant microbiome profile in infants. 2019; in press
33. Myers LC, Faridi MK, Hasegawa K, Hanania N, Camargo CA Jr. The Hospital Readmissions Reduction Program and readmissions for patients with chronic obstructive pulmonary disease, 2006-2015. Ann Am Thorac Soc 2019; in press
34. Fujiogi M, Camargo CA Jr., Bernot JP, Freishtat RJ, Harmon B, Mansbach JM, Castro-Nallar E, Perez-Losada M, Hasegawa K. In infants with severe bronchiolitis: Dual-transcriptomic profiling of nasopharyngeal microbiome and host response. Pediatr Res 2019; in press

Review articles in 2019
1. Invited Review. Goto T, Goto Y, Hagiwara Y, Okamoto H, Watase H, Hasegawa K. Advancing emergency airway management practice and research. Acute Med Surg 2019; Epub ahead of print
2. Zhu Z, Camargo CA Jr, Hasegawa K. Metabolomics in the prevention and management of asthma. Expert Rev Respir Med 2019; in press